The undiagnosed diseases network (UDN) is a NIH-funded initiative that is intended to build upon the very successful undiagnosed disease program (UDP) of the NIH. The UDN provides a national network of clinical and research sites that are capable of providing a high-quality set of diagnostic protocols that will enable the diagnosis of previously undiagnosed patients. The UDN is also intended to aggregate and develop new knowledge, insights, policies and procedures that increase efficiencies and enable research innovations that facilitate greater disease knowledge and the rapid and accurate diagnosis of greater numbers of patients.

The UDN Patient and Investigator Gateway

Functional Overview
The UDN Gateway is the primary point of entry for patients into the UDN and also serves as a referral engine for suggesting clinical site assignments for each accepted applicant. Core essential functions and requirements of the Gateway are enumerated below:

1. Patient registration
2. Assignment of a unique patient identifier
3. Patient application to the UDN
4. Ability for physicians/parent/guardian to apply on behalf of patients
5. Collection of minimum patient personal data, medical history data
6. Collection of data on referring physician
7. Ability for patient to enter and upload data, save, return to and complete a partially completed application
8. Ability for a patient to withdraw an application and request the return/destruction of patient-provided data
9. Collection/upload of a physician referral letter
10. Logic that provides an initial UDN clinical site referral based upon patient provided information
11. Ability for UDN CC personnel to review, approve or abort UDN clinical site referral recommendations
12. Ability to view the current status of all applications via a dashboard or some other visualization method
13. Ability, in a fully compliant manner, for UDN clinical sites to review data about individual patients
14. Roles based user and administrator access
15. Adequate information security controls
16. HIPAA compliance

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