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 Home  Services Overview  Compliance  21 CFR Part 11 Compliance
OVERVIEW

With the current trend of corporations transforming their operations to a paperless environment, regulated industries are facing issues of validity and compliance of their computer systems and applications.  The challenge of keeping pace with the impact of technology on their operations, while addressing and meeting new guidelines and regulations, has become an imperative and time consuming task.  In order to permit the use of electronic technology in FDA-regulated industries, including pharmaceutical, biotechnology, medical devices, etc., the new 21 CFR Part 11 regulations regarding security, traceability, and integrity of electronic records and electronic signatures need to be enforced for all computer systems.

Working with a professional IT & Turn-key Automation Engineering and Consulting firm such as Xyntek, with hands-on technical expertise and in-depth knowledge of Computer System Validation in the regulatory environment, you can ensure that your company's Part 11 requirements will be completed in a cost effective and efficient manner. Xyntek's team of validation and automation professionals are fully trained and experienced on 21 CFR PART 11 requirements, and are ready to assist your company with the issues and challenges in hand.  Our services include:

  • Increase company wide awareness and knowledge of 21 CFR Part 11
    Provide detailed compliance strategy for new and legacy systems
  • Conduct full system assessments on all of your company's GxP systems and develop a Gap Analysis that will result in a 21 CFR Part 11 compliant solution
  • Review and research technology issues that will provide remediation actions for Part 11 gaps and/or features
  • Recommend, and implement technology tools for electronic records and electronic signatures
METHODOLOGY

Xyntek team utilizes a risk-based approach in their assessment activities to more adequately recommend remediation solutions.  This approach assesses the entire system and associated process, and covers regulatory risks and business risks. Also, Xyntek builds its own Interpretation of the FDA Final Rule on Electronic Records and Electronic Signatures (21 CFR Part 11) , and forms a set of assessment tool to validate the Electronic Records and Electronic Signatures compliance.

INTERACTIVE
CASE STUDY
21 CFR Part 11 Compliance Service for a Top Three Pharmaceutical Company
Xyntek assisted one of the major pharmaceutical companies to bring their several computerized systems in multiple sites worldwide to become compliant with 21 CFR part 11 regulations. Systems that were brought into compliance included CyberLAB - a knowledge engineering system, Millennium Empower - a data acquisition and instrumentation control application, Laboratory Automated Data Collection (LADC) and Laboratory Automated System (LAS) - data acquisition applications used to collect raw data generated by the instruments, and Datatox - a LIMS for data collection and statistical process control for Toxicology and Pathology data. Throughout the project, qualified Xyntek professionals identified part 11 gaps for all the systems, developed System Evaluation and Action Plans (SEAPs), System Implementation Plans (SIPs) and 21 CFR Corrective Action Plans (CAPs) to provide remediation solutions to the identified part 11 gaps.
Validation and Compliance in Pharmaceutical Manufacturing
With our expertise in regulatory compliance, Xyntek assisted a major medical device manufacturing company in planning and implementation of their 21 CFR Part 11 Compliance Program. The project was implemented in three plants in Peuto Rico and entailed the complete Part 11 assessments and remediation of IM systems, PLC-based manufacturing systems, machine vision applications, and laboratory instruments. Xyntek was selected to manage and perform all activities required to address Part 11 issues and to align remediation efforts with future business requirements and plans. The actions taken to bring the organization�?????�????�???�??�?�¢??s systems into compliance with 21 CFR Part 11 eliminated the risk and liability to regulatory penalties and improved business practices.
R&D Labs Compliance
Xyntek has followed a proven Software Development Life Cycle (SDLC) Methodology to ensure timely and orderly development of the validation documentation for the client�?????�????�???�??�?�¢??s GLP and GMP laboratory systems, which needed to be rendered 21 CFR Part 11 compliant. System that was made 21 CFR Part 11 compliant included instruments by TECAN, Bio-Rad, BD BioSciences, and Thermo Electron. The validation documents include the Validation Plan, Functional Requirements Specification, Installation Operational Qualification (IOQ) Protocol, User Acceptance Testing (UAT) Protocol, IOQ and UAT Summary Reports, Validation Report, and Standard Operating Procedures (SOPs).
CONTACT US

For more information on Xyntek's providison of the FDA regulated companies an easy and reliable technical remediation solution, please contact us here.